Production of end products. An intersectoral national economic complex is a set of industries that are directly or indirectly involved in the production of final products.

"Pannuvladinum" - sresies.

VFS RK 42-1257-04.

Tetracycline

active substances:

tetracycline 10 mg;
Excipients :

lanolin anhydrous

Description.

Microscopy.

Indications for use.

Blepharitis (inflammation of the eyelids);

Contraindications

Children's age up to 8 years

Side effects

allergic reactions

Hyperemia and edema of veins

Methods of application and doses

Overdose

Not identified

Storage conditions

Shelf life

Terms of dispensing from pharmacies

Over the counter

Chemical scheme of production

In the production of the collection of medicinal plant raw materials "Pannuvadin" chemical transformations do not occur.

Technological scheme of production

Product certification

Tetracycline Lanolin Vaseline Tubalards

toltyruga dayyndau

Өlsheu Өlsheu Өlsheu Zhuu

Balkytu Sterildeu

Sterildeu

Negizdin kuramyna engizu

Homogenizationlau

Sapasyn bagalau

Bolshekteu

Oramdau cardboard pack

Dayyn onim

Hardware scheme production and equipment specification

Scheme number	Name of equipment	Number of units	Working part material	Technical specifications

VR-1 Preparation of raw materials
UWB	Shelf dryer		Collection	Overall dimensions 6000x500x2800 cm. Number of shelves 24. Dimensions of pallets 1300x1200x30 cm with mesh at the bottom, mesh size 2x2 mm. Electric heating with a thermostat, using a closed-type battery (PBZ-2) - 4 pcs. Power 2 kW. BB-300 type fan - 2 pcs., power 0.3 kW.
KDU-1	Feed crusher universal		Collection	Chopper type KDU-2m. The installed power of the electric motor is 15 kW. Blade rotation speed 2800 rpm. Grinding degree from 1 to 4 mm
KS	Sieve set		stainless steel Steel
TP-1. Receipt finished product
Sun 1	Scales		Collection	Scales. Weighing limits 0 -160 kg. Division value 200 g.
Sun 2	Scales		Collection	Scales are technical. Weighing limits 0.1-200 g Scale division 0.1 g.

cm 1	Mixer for vegetable raw materials		Collection	Drum mixer. The installed power of the electric motor is 3 kW. Drum rotation speed 9 rpm.
UMO-1. Packaging, labeling and clearance
Sru-1	Table manual packaging and design			Designed for manual packaging and labeling

VR-I. Raw material preparation

VR-I. 2. Grinding and sieving of medicinal

vegetable raw materials

Crushers of the KDU-2m type are used for grinding vegetable raw materials. Sifting pieces of leaves and stems various shapes carried out through a sieve with a hole with a diameter of 3-4 mm.

Before operation, the crusher and the set of sieves are freed from dust and mechanical impurities. Be sure to check the grounding of the equipment and the presence of casings. Operators serving this equipment should be provided with respirators or gauze bandages protecting the upper respiratory tract, as well as safety glasses.

a) Grinding and sifting peppermint leaves

4 kg of peppermint leaves with a moisture content of not more than 14% enter production at the stage VR-1.2 “Crushing of medicinal plant materials”. After crushing and sifting, 3.96 kg of crushed peppermint leaves were obtained.

Losses amounted to 1%.

b) Grinding plantain leaves

4 kg of plantain leaves with a moisture content of not more than 14% enter production at the stage VR-1.2 “Crushing of medicinal plant raw materials”. Crushers of the KDU-2m type are used for grinding vegetable raw materials. Sifting pieces of leaves and stems of various shapes through a sieve with a hole with a diameter of 3-4 mm. After crushing and sieving, 3.96 kg of crushed plantain leaves were obtained.

Losses amounted to 1%.

c) Grinding herb wormwood

20 kg of wormwood herb with a moisture content of not more than 13% enters production at stage VR-1.2 “Crushing of medicinal plant raw materials”. Crushers of the KDU-2m type are used for grinding vegetable raw materials. Sifting pieces of leaves and stems of various shapes through a sieve with a hole with a diameter of 3-4 mm. After crushing and sifting, 3.96 kg of crushed wormwood herb was obtained.

Losses amounted to 1%.

d) Grinding the grass of Gerard's rush

4 kg of Sitnik Gerard herb with a moisture content of not more than 12% enters production at the stage VR-1.2 “Crushing of medicinal plant raw materials”. Crushers of the KDU-2m type are used for grinding vegetable raw materials. Sifting pieces of leaves and stems of various shapes through a sieve with a hole with a diameter of 3-4 mm. After crushing and sieving, 3.96 kg of crushed herb Sitnik Gerard was obtained.

Losses amounted to 1%.

e) Grinding herb cochia broom

4 kg of cochia broom herb with a moisture content of not more than 14% enters production at the stage VR-1.1 “Crushing of medicinal plant raw materials”. Crushers of the KDU-2m type are used for grinding vegetable raw materials. Sifting pieces of leaves and stems of various shapes through a sieve with a hole with a diameter of 3-4 mm. After crushing and sifting, 3.96 kg of crushed kochia broom herb was obtained.

Losses amounted to 1%.

Large inclusions of stems and roots of plants larger than 10 mm after sifting through sieves with a diameter of 7 mm amounted to no more than 1% of the mass of the processed medicinal raw materials. This fraction in the form of waste is taken out by road to the dump.

Gathering "Pannuvladin"

The collection is packaged with a mass of 10 g in plastic bags according to GOST 12302. Eight plastic bags are placed in a pack of chrome-ersatz cardboard TU 13-0281020-97-90 or cardboard for consumer packaging in accordance with GOST 7933-89. The packs are wrapped with a film of the PC-2 brand (Certificate of Conformity No. KK.646092.01.0107279).

Group and shipping containers in accordance with GOST 17768-90.

Marking. On the pack indicate the Republic of Kazakhstan, Aldiyar-Pharm LLP, TsAAMB LLP, the legal address of the manufacturer, the name of the collection in the state, Latin and Russian languages, the method of application, storage conditions, the amount of the drug in grams, the inscription "Products passed radiation control ”, series, expiration date.

Packages that do not meet the requirements are torn apart. Raw materials are released from packaging, inspected and repackaged.

Product losses during packaging are 3%, i.e. 0.6 kg.

Packing angro 50 kg. Packed in fabric bags according to GOST 19317-73 or flax-jutokenaf according to GOST 18225-72. When packing raw materials in double bags, one bag is first inserted into the other. Bags filled with raw materials must be sewn manually with bast fiber twine in accordance with GOST 17308-85 or linen threads in accordance with GOST 14961-85 stitches at least 2 cm or machine-made with a chain double seam.

When sewing the bag by machine, a comb with a width of at least 5 cm must remain above the seam. When sewing the bag manually, two ears with a length of at least 10 cm must be made in the upper part of the bags. When packing raw materials in double bags, both bags are sewn simultaneously. Bags must be sewn with a cross seam: first they are sewn in one direction, then in the opposite direction - with stitches at a distance of no more than 4 cm. The mass of raw materials packed in a bag must be 50 kg net. Shipping container marking in accordance with GOST 14192-96.

Transportation in accordance with GOST 17768-90.

material balance

Security environment

Air emissions

Release name

Name of emission sources (stages, devices, ventilation units)

The amount of emission per 1 kg of products, kg

Periodicity of emission per day, hour.

Emission sources and gas-air mixture parameters

Emission regulations

Actual emission value

Number of sources

Height, m

Diameter, m

Volume, m3

Temperature, 0 С

Name of indicators of permissible emissions

unit of measurement

The value of the standard

There are no emissions polluting the environment in the production of the Pannuvladin medicinal collection

Characteristics of the final product of production

Pannuvladin – d¸ðiëiê ¼ñiìäiê shikiçattardy» zhyynty¹û.

Pannuvladin - collection of medicinal plant materials

"Pannuvladinum" - sresies.

VFS RK 42-1257-04.

Tetracycline

Composition per 1 g of the drug, in milligrams:
active substances:

tetracycline 10 mg;
Excipients:

lanolin anhydrous

Description.

Microscopy.

Vaseline - Homogeneous, odorless ointment mass stretching with threads, from white to yellow. When smeared on a glass plate, it gives an even, non-slip film. When melted, it gives a clear liquid with a slight odor of paraffin or oil.

Lanoloin - A thick, viscous yellow or brownish-yellow mass, with a peculiar smell, melting at a temperature of 36 - 42 ° C. It differs from other waxes by its high content of sterols (in particular, cholesterol). It is well absorbed into the skin and has a softening effect. The composition of lanolin is very complex and has not been fully studied to date. Basically, it is a mixture of esters of macromolecular alcohols (cholesterol, isocholesterol, etc.) with higher fatty acids (myristic, palmitic, cerotinic, etc.) and free macromolecular alcohols. According to its properties, lanolin is close to human sebum. In chemical terms, it is quite inert, neutral and stable during storage. The most valuable property of lanolin is its ability to emulsify up to 180-200% (of its own weight) of water, up to 140% of glycerol and about 40% of ethanol (70% concentration) to form water/oil type emulsions. Additives of a small amount of lanolin to fats and hydrocarbons sharply increase their ability to mix with water and aqueous solutions, which led to its widespread use in the composition of lipophilic-hydrophilic bases.

Numerical indicators. essential oil not less than 0.5%; polysaccharides not less than 3%; loss in mass during drying is not more than 10%; total ash no more than 10%; ash insoluble in 10% hydrochloric acid, not more than 3%; parts of plants that have changed their original color, not more than 1%; particles that do not pass through a sieve with holes of 7 mm, not more than 10%; particles passing through a sieve with a hole diameter of 0.5 mm, not more than 10%; organic impurities not more than 1%; mineral impurities not more than 0.5%; heavy metals no more than 0.001%.

Microbiological purity. The collection must meet the requirements of GF X1, vol. 1, p. 193.

In 1 g of raw materials, no more than 10 7 aerobic bacteria and 10 5 yeast and mold fungi (total), Escherichia coli no more than 10 2 are allowed.

Methods of qualitative reactions and quantitative determination are presented in VFS RK 42-1257-04.

pharmacological properties. Hepatoprotective, anti-inflammatory agent:

It has a reparative stabilizing effect on liver cells;

Favorably affects the detoxifying function of the liver;

Helps protect the liver tissue and activate the processes of its recovery;

Improves the outflow of bile through the intrahepatic passages and ducts;

Increases the intensity of the antioxidant system of the liver;

Reduces the activity of liver enzymes in the blood serum.

Indications for use.

Conjunctivitis (inflammation of the mucous membrane of the eye);

Blepharitis (inflammation of the eyelids);

Keratitis (inflammation of the cornea of the eye);

Trachoma ( infectious disease eye).

Contraindications

Hypersensitivity to the components of the drug

Renal and liver failure

Pregnancy, lactation

Children's age up to 8 years

Side effects

allergic reactions

Hyperemia and edema of veins

Transient blurred vision

Methods of application and doses

Locally, lay for the lower eyelid 3-5 times a day.

Blepharitis: 3-4 times a day for 10 days.

Bacterial keratitis, keratoconjunctivitis: 2-3 times a day for 10 days. If the condition does not improve within 3-5 days, you should consult your doctor.

Meibomite (barley): at night until the symptoms of inflammation disappear.

Trachoma: every 2-4 hours or more often for 1-2 weeks. The duration of the course of treatment of trachoma should not exceed 1-2 months.

Overdose

Not identified

Storage conditions

To store in the place protected from light, at a temperature no more than 15 °C.

Shelf life

Storage after the first opening of the package is no more than 5 weeks.

Do not use after the expiration date

Terms of dispensing from pharmacies

The main requirement when calculating GDP and GNP indicators is that all goods and services produced in a year are taken into account only once, that is, that only final products are taken into account in the calculation, and intermediate products that can be bought and resold many times are not taken into account. GDP and GNP reflect performance in 2 areas National economy- material production and services; both are defined as the value of the total volume of final production of goods and services in the economy for 1 year (quarter, month). End products are goods and services that are bought by consumers for final use and not for resale. Intermediate products are goods and services that are further processed or resold several times before reaching the final consumer. If we sum up the goods and services produced in the country in all sectors of the economy, then repeated repeated counting is inevitable, significantly distorting the real volume of the gross domestic product produced. Let's take the following illustrative example. Say grain grown in agriculture, before turning into the final product - bread, goes through four stages of processing:

collection, threshing and sorting of grain in agriculture;
cleaning, drying and storage in elevators;
grinding grain in mills;
baking bread at the bakery.

If we assume that the price of grain produced in agriculture is "P" units, then during its processing and processing at the next three stages, this price is included three more times in the production costs at the elevator, mill and bakery, and, ultimately, four times summed up when calculating the volume of production. In fact, the real value created at each stage of grain processing and covering the cost of production and income should appear only in the form wages, depreciation and profit of this particular enterprise. Therefore, to avoid repeated counting, GDP and GNP should act as the cost of final goods and services and include only the value created (added) at each intermediate stage of processing.

Send your good work in the knowledge base is simple. Use the form below

Students, graduate students, young scientists who use the knowledge base in their studies and work will be very grateful to you.

Production of end products. An intersectoral national economic complex is a set of industries that are directly or indirectly involved in the production of final products.

Send your good work in the knowledge base is simple. Use the form below

Similar Documents